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Table 3 Spearman’s rank correlation with Aβ to extract CAA-specific and vascular-specific pathological changes

From: Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method

 

Capillary

Parenchyma

11 donors including CAA (ADNC +/CAA + & ADNC −/CAA −)

10 donors including AD (ADNC +/CAA- & ADNC −/CAA −)

11 donors including CAA (ADNC +/CAA + & ADNC − −/CAA −)

10 donors including AD (ADNC +/CAA − & ADNC −/CAA −)

ρ

p

ρ

p

ρ

p

ρ

p

Aβ

1.00

–

1.00

–

1.00

–

1.00

–

ECM related protein

 COL6A1

0.855

8.07E−04**

0.467

1.74E−01

0.273

4.17E−01

0.309

3.85E−01

 FBN1

0.800

3.11E−03**

0.515

1.28E−01

− 0.0636

8.53E−01

0.527

1.17E−01

 COL6A2

0.782

4.47E−03**

0.370

2.93E−01

− 0.0909

7.90E−01

0.406

2.44E−01

 COL6A3

0.691

1.86E−02*

0.297

4.05E−01

− 0.100

7.70E−01

0.261

4.67E−01

Cell adhesion related protein

 CD44

0.645

3.20E−02*

0.661

3.76E−02*

0.327

3.26E−01

0.539

1.08E−01

 HEPACAM

0.618

4.26E−02*

0.418

2.29E−01

− 0.536

8.90E−02

0.333

3.47E−01

 PCBP1

− 0.809

2.56E−03**

− 0.624

5.37E−02

− 0.264

4.33E−01

0.612

6.00E−02

Fibrosis related protein

 HSP90A

0.764

6.23E−03**

− 0.0667

8.55E−01

0.227

5.02E−01

0.236

5.11E−01

 LDHA

0.727

1.12E−02*

0.164

6.51E−01

0.00909

9.79E−01

0.188

6.03E−01

 S100A6

0.664

2.60E−02*

0.115

7.51E−01

0.264

4.33E−01

− 0.273

4.46E−01

 PML

0.636

3.53E−02*

0.527

1.17E−01

− 0.0818

8.11E−01

0.273

4.46E−01

 DUSP3

− 0.782

4.47E−03**

− 0.139

7.01E−01

− 0.445

1.70E−01

0.103

7.77E−01

ROS related protein

 APOE

0.827

1.68E−03**

0.321

3.65E−01

0.582

6.04E−02

0.467

1.74E−01

 GNG12

0.700

1.65E−02*

0.673

3.30E−02*

− 0.00909

9.79E−01

0.382

2.76E−01

 GSTO1

0.673

2.33E−02*

− 0.0545

8.81E−01

0.191

5.74E−01

− 0.273

4.46E−01

 IGHG1

0.655

2.89E−02*

0.309

3.85E−01

0.0818

8.11E−01

0.370

2.93E−01

Antioxidant related protein

 GFAP

0.864

6.12E−04**

0.200

5.80E−01

0.509

1.10E−01

− 0.224

5.33E−01

 PRDX2

0.727

1.12E−02*

0.139

7.01E−01

− 0.182

5.93E−01

− 0.224

5.33E−01

 CYB5R3

0.655

2.89E−02*

0.527

1.17E−01

− 0.136

6.89E−01

0.164

6.51E−01

 CLU

0.655

2.89E−02*

0.176

6.27E−01

0.509

1.10E−01

− 0.0303

9.34E−01

 PRDX6

0.627

3.88E−02*

− 0.236

5.11E−01

0.218

5.19E−01

− 0.0182

9.60E−01

Akt related protein

 PDHX

− 0.791

3.75E−03**

− 0.127

7.26E−01

− 0.0818

8.11E−01

0.309

3.85E−01

 NCSTN

− 0.782

4.47E−03**

− 0.285

4.25E−01

− 0.0182

9.58E−01

− 0.00606

9.87E−01

 TPD52L2

− 0.691

1.86E−02*

− 0.333

3.47E−01

− 0.0818

8.11E−01

− 0.0909

8.03E−01

 PSMC2

− 0.664

2.60E−02*

− 0.370

2.93E−01

0.0182

9.58E−01

− 0.297

4.05E−01

Caspase related protein

 HEBP1

0.691

1.86E−02*

0.697

2.51E−02*

− 0.455

1.60E−01

0.0788

8.29E−01

 CA1

0.645

3.20E−02*

0.139

7.01E−01

− 0.0455

8.94E−01

0.345

3.28E−01

 TUBB2B

− 0.845

1.05E−03**

− 0.345

3.28E−01

0.109

7.50E−01

0.418

2.29E−01

 ACOX1

− 0.882

3.30E−04**

− 0.770

9.22E−03**

− 0.327

3.26E−01

− 0.285

4.25E−01

 ATP2A2

− 0.873

4.55E−04**

− 0.382

2.76E−01

− 0.409

2.12E−01

0.333

3.47E−01

 PTGES3

− 0.736

9.76E−03**

− 0.00606

9.87E−01

− 0.364

2.72E−01

0.455

1.87E−01

 PRKAR2B

− 0.736

9.76E−03**

− 0.455

1.87E−01

0

–

0.273

4.46E−01

 TUBB4A

− 0.718

1.28E−02*

− 0.200

5.80E−01

− 0.309

3.55E−01

0.442

2.00E−01

 PPP2R2A

− 0.691

1.86E−02*

− 0.00606

9.87E−01

− 0.245

4.67E−01

0.358

3.10E−01

 TUBB6

− 0.664

2.60E−02*

− 0.382

2.76E−01

0.145

6.70E−01

0.152

6.76E−01

Others

 KANK2

0.773

5.30E−03**

0.0909

8.03E−01

0.618

4.26E−02*

− 0.0788

8.29E−01

 VARS

− 0.945

1.12E−05**

− 0.661

3.76E−02*

− 0.364

2.72E−01

− 0.0303

9.34E−01

 ACTN2

− 0.818

2.08E−03**

− 0.479

1.62E−01

− 0.218

5.19E−01

0.0788

8.29E−01

 EXOC6B

− 0.800

3.11E−03**

− 0.188

6.03E−01

− 0.327

3.26E−01

− 0.176

6.27E−01

 HSPH1

− 0.709

1.46E−02*

− 0.261

4.67E−01

− 0.227

5.02E−01

− 0.0303

9.34E−01

 SV2B

− 0.709

1.46E−02*

− 0.382

2.76E−01

− 0.445

1.70E−01

0.248

4.89E−01

 ETFA

− 0.700

1.65E−02*

0.224

5.33E−01

0.0182

9.58E−01

0.0182

9.60E−01

 FARSA

− 0.691

1.86E−02*

− 0.309

3.85E−01

0

–

− 0.0788

8.29E−01

  1. The 43 proteins listed in this table (except for Aβ) were chosen by the two selections as follows; (1) proteins that showed more than 1.5-fold difference in the average expression levels between six ADNC +/CAA + and five ADNC −/CAA − donors for the collected capillaries, and (2) proteins that are significantly (p < 0.05) correlated with Aβ in the capillary samples of 11 donors (6 ADNC +/CAA + and 5 ADNC −/CAA − donors) based on Spearman’s rank correlation analysis. The ρ and p values of Spearman’s rank correlation were listed for four conditions; 11 donors’ capillaries (6 ADNC +/CAA + and 5 ADNC −/CAA − donors), 10 donors’ capillaries (5 ADNC +/CAA − and 5 ADNC −/CAA − donors), 11 donors’ parenchyma (6 ADNC +/CAA + and 5 ADNC −/CAA − donors), and 10 donors’ parenchyma (5 ADNC +/CAA − and 5 ADNC −/CAA − donors)
  2. *p < 0.05
  3. **p < 0.01, significantly correlation with Aβ
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Fluids and Barriers of the CNS

ISSN: 2045-8118