Capillary | Parenchyma | |||||||
---|---|---|---|---|---|---|---|---|
11 donors including CAA (ADNC +/CAA + & ADNC −/CAA −) | 10 donors including AD (ADNC +/CAA- & ADNC −/CAA −) | 11 donors including CAA (ADNC +/CAA + & ADNC − −/CAA −) | 10 donors including AD (ADNC +/CAA − & ADNC −/CAA −) | |||||
ρ | p | ρ | p | ρ | p | ρ | p | |
Aβ | 1.00 | – | 1.00 | – | 1.00 | – | 1.00 | – |
ECM related protein | ||||||||
COL6A1 | 0.855 | 8.07E−04** | 0.467 | 1.74E−01 | 0.273 | 4.17E−01 | 0.309 | 3.85E−01 |
FBN1 | 0.800 | 3.11E−03** | 0.515 | 1.28E−01 | − 0.0636 | 8.53E−01 | 0.527 | 1.17E−01 |
COL6A2 | 0.782 | 4.47E−03** | 0.370 | 2.93E−01 | − 0.0909 | 7.90E−01 | 0.406 | 2.44E−01 |
COL6A3 | 0.691 | 1.86E−02* | 0.297 | 4.05E−01 | − 0.100 | 7.70E−01 | 0.261 | 4.67E−01 |
Cell adhesion related protein | ||||||||
CD44 | 0.645 | 3.20E−02* | 0.661 | 3.76E−02* | 0.327 | 3.26E−01 | 0.539 | 1.08E−01 |
HEPACAM | 0.618 | 4.26E−02* | 0.418 | 2.29E−01 | − 0.536 | 8.90E−02 | 0.333 | 3.47E−01 |
PCBP1 | − 0.809 | 2.56E−03** | − 0.624 | 5.37E−02 | − 0.264 | 4.33E−01 | 0.612 | 6.00E−02 |
Fibrosis related protein | ||||||||
HSP90A | 0.764 | 6.23E−03** | − 0.0667 | 8.55E−01 | 0.227 | 5.02E−01 | 0.236 | 5.11E−01 |
LDHA | 0.727 | 1.12E−02* | 0.164 | 6.51E−01 | 0.00909 | 9.79E−01 | 0.188 | 6.03E−01 |
S100A6 | 0.664 | 2.60E−02* | 0.115 | 7.51E−01 | 0.264 | 4.33E−01 | − 0.273 | 4.46E−01 |
PML | 0.636 | 3.53E−02* | 0.527 | 1.17E−01 | − 0.0818 | 8.11E−01 | 0.273 | 4.46E−01 |
DUSP3 | − 0.782 | 4.47E−03** | − 0.139 | 7.01E−01 | − 0.445 | 1.70E−01 | 0.103 | 7.77E−01 |
ROS related protein | ||||||||
APOE | 0.827 | 1.68E−03** | 0.321 | 3.65E−01 | 0.582 | 6.04E−02 | 0.467 | 1.74E−01 |
GNG12 | 0.700 | 1.65E−02* | 0.673 | 3.30E−02* | − 0.00909 | 9.79E−01 | 0.382 | 2.76E−01 |
GSTO1 | 0.673 | 2.33E−02* | − 0.0545 | 8.81E−01 | 0.191 | 5.74E−01 | − 0.273 | 4.46E−01 |
IGHG1 | 0.655 | 2.89E−02* | 0.309 | 3.85E−01 | 0.0818 | 8.11E−01 | 0.370 | 2.93E−01 |
Antioxidant related protein | ||||||||
GFAP | 0.864 | 6.12E−04** | 0.200 | 5.80E−01 | 0.509 | 1.10E−01 | − 0.224 | 5.33E−01 |
PRDX2 | 0.727 | 1.12E−02* | 0.139 | 7.01E−01 | − 0.182 | 5.93E−01 | − 0.224 | 5.33E−01 |
CYB5R3 | 0.655 | 2.89E−02* | 0.527 | 1.17E−01 | − 0.136 | 6.89E−01 | 0.164 | 6.51E−01 |
CLU | 0.655 | 2.89E−02* | 0.176 | 6.27E−01 | 0.509 | 1.10E−01 | − 0.0303 | 9.34E−01 |
PRDX6 | 0.627 | 3.88E−02* | − 0.236 | 5.11E−01 | 0.218 | 5.19E−01 | − 0.0182 | 9.60E−01 |
Akt related protein | ||||||||
PDHX | − 0.791 | 3.75E−03** | − 0.127 | 7.26E−01 | − 0.0818 | 8.11E−01 | 0.309 | 3.85E−01 |
NCSTN | − 0.782 | 4.47E−03** | − 0.285 | 4.25E−01 | − 0.0182 | 9.58E−01 | − 0.00606 | 9.87E−01 |
TPD52L2 | − 0.691 | 1.86E−02* | − 0.333 | 3.47E−01 | − 0.0818 | 8.11E−01 | − 0.0909 | 8.03E−01 |
PSMC2 | − 0.664 | 2.60E−02* | − 0.370 | 2.93E−01 | 0.0182 | 9.58E−01 | − 0.297 | 4.05E−01 |
Caspase related protein | ||||||||
HEBP1 | 0.691 | 1.86E−02* | 0.697 | 2.51E−02* | − 0.455 | 1.60E−01 | 0.0788 | 8.29E−01 |
CA1 | 0.645 | 3.20E−02* | 0.139 | 7.01E−01 | − 0.0455 | 8.94E−01 | 0.345 | 3.28E−01 |
TUBB2B | − 0.845 | 1.05E−03** | − 0.345 | 3.28E−01 | 0.109 | 7.50E−01 | 0.418 | 2.29E−01 |
ACOX1 | − 0.882 | 3.30E−04** | − 0.770 | 9.22E−03** | − 0.327 | 3.26E−01 | − 0.285 | 4.25E−01 |
ATP2A2 | − 0.873 | 4.55E−04** | − 0.382 | 2.76E−01 | − 0.409 | 2.12E−01 | 0.333 | 3.47E−01 |
PTGES3 | − 0.736 | 9.76E−03** | − 0.00606 | 9.87E−01 | − 0.364 | 2.72E−01 | 0.455 | 1.87E−01 |
PRKAR2B | − 0.736 | 9.76E−03** | − 0.455 | 1.87E−01 | 0 | – | 0.273 | 4.46E−01 |
TUBB4A | − 0.718 | 1.28E−02* | − 0.200 | 5.80E−01 | − 0.309 | 3.55E−01 | 0.442 | 2.00E−01 |
PPP2R2A | − 0.691 | 1.86E−02* | − 0.00606 | 9.87E−01 | − 0.245 | 4.67E−01 | 0.358 | 3.10E−01 |
TUBB6 | − 0.664 | 2.60E−02* | − 0.382 | 2.76E−01 | 0.145 | 6.70E−01 | 0.152 | 6.76E−01 |
Others | ||||||||
KANK2 | 0.773 | 5.30E−03** | 0.0909 | 8.03E−01 | 0.618 | 4.26E−02* | − 0.0788 | 8.29E−01 |
VARS | − 0.945 | 1.12E−05** | − 0.661 | 3.76E−02* | − 0.364 | 2.72E−01 | − 0.0303 | 9.34E−01 |
ACTN2 | − 0.818 | 2.08E−03** | − 0.479 | 1.62E−01 | − 0.218 | 5.19E−01 | 0.0788 | 8.29E−01 |
EXOC6B | − 0.800 | 3.11E−03** | − 0.188 | 6.03E−01 | − 0.327 | 3.26E−01 | − 0.176 | 6.27E−01 |
HSPH1 | − 0.709 | 1.46E−02* | − 0.261 | 4.67E−01 | − 0.227 | 5.02E−01 | − 0.0303 | 9.34E−01 |
SV2B | − 0.709 | 1.46E−02* | − 0.382 | 2.76E−01 | − 0.445 | 1.70E−01 | 0.248 | 4.89E−01 |
ETFA | − 0.700 | 1.65E−02* | 0.224 | 5.33E−01 | 0.0182 | 9.58E−01 | 0.0182 | 9.60E−01 |
FARSA | − 0.691 | 1.86E−02* | − 0.309 | 3.85E−01 | 0 | – | − 0.0788 | 8.29E−01 |