Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus

Table 2 Expression levels, the fold change (Log₂FC), and the % change of main transporters, channels and carbonic anhydrases in the rats choroid plexus after treatment with either control solution (CTRL) or 100 mg ml⁻¹ AZE p.o. for 7 days (AZE), in transcripts per million (TPM). Control values for carbonic anhydrases are those from Table 1

	Gene	Alias	Description	CTRL	AZE	Log₂FC	% change
Carbonic anhydrases	CA2	CAII	Carbonic anhydrase 2	785	715	− 0.14	− 9
	CA14	CAXIV	Carbonic anhydrase 14	92	102	0.15	11
	CA4	CAIV	Carbonic anhydrase 4	15	7.3	− 1.03	− 51
	CA12	CAXII	Carbonic anhydrase 12	13	30	1.26	140
	CA11	CAXI	Carbonic anhydrase 11	10	9.1	− 0.10	− 6
	CA6	CAVI	Carbonic anhydrase 6	8.4	6.7	− 0.33	− 21
	CA13	CAXIII	Carbonic anhydrase 13	7.2	10	0.48	40
	CA9	CAIX	Carbonic anhydrase 9	2.9	4.4	0.60	51
	CA5B	CAVB	Carbonic anhydrase 5B	2.8	2.3	− 0.27	− 17
	CA3	CAIII	Carbonic anhydrase 3	0.6	0.7	0.17	12
Channels	KCNJ13	Kir7.1	Inwardly rectifying K⁺ channel 7.1	192	237	0.31	24
	AQP1	AQP1	Aquaporin 1	161	197	0.30	23
	TRPV4	TRPV4	Transient receptor potential vanilloid channel 4	34	38	0.18	13
	CLCN6	ClC-6	Voltage-gated Cl⁻ channel 6	3.9	4.4	0.18	13
Transporters	FXYD1	FXYD1	Na⁺/K⁺-ATPase γ1	1449	1861	0.36	28
	ATP1B1	NKA.b1	Na⁺/K⁺-ATPase β1	365	370	0.02	1
	ATP1B2	NKA.b2	Na⁺/K⁺-ATPase β2	158	132	− 0.26	− 16
	SLC12A2	NKCC1	Na⁺, K⁺, 2Cl⁻ cotransporter	96	93	− 0.04	− 3
	ATP1A1	NKA.a1	Na⁺/K⁺-ATPase α1	82	117	0.52	44
	SLC4A2	AE2	Cl⁻, HCO₃⁻ exchanger	77	106	0.46	38
	SLC4A10	NCBE	Na⁺, HCO₃⁻ cotransporter	54	56	0.04	3
	SLC12A4	KCC1	K⁺, Cl⁻ cotransporter	40	49	0.28	21
	SLC12A7	KCC4	K⁺, Cl⁻ cotransporter 4	40	35	− 0.19	− 12
	SLC4A5	NBCE2	Na⁺, HCO₃⁻ cotransporter	38	68	0.85	80
	SLC9A6	NHE6	Na⁺, H⁺ exchanger 6	6.8	7.3	0.12	9
	SLC9A1	NHE1	Na⁺, H⁺ exchanger 1	3.7	3.0	− 0.31	− 20
	SLC12A6	KCC3	K⁺, Cl⁻ cotransporter 3	3.1	2.3	− 0.45	− 27

ISSN: 2045-8118