Fig. 1
Effect of i.v. administration of AZE in anesthetized and ventilated rats. The ICP (A), MAP (C) and etCO2 (E) is presented as 5 min average values normalized to the baseline (10 min average value obtained before control solution or AZE administration, 100 mg kg−1) as a function of time. The change from baseline at 2 h after the injection is shown for ICP (B, n = 5, P < 0.01, unpaired t-test) and MAP (D, n = 5, P = 0.9, unpaired t-test). Blood gas analysis was performed before (0 h) and 1 and 2 h after the injection, and results are presented for pCO2 (F, n = 5, P > 0.9 at 0 h, P < 0.001 at 1 and 2 h, 2way ANOVA with Bonferroni’s post-hoc analysis) and for blood HCO3− (G, n = 5, P < 0.001 for time variable, P < 0.05 for treatment variable, shown above bars, 2way ANOVA). Arrow indicates time of i.v. injection. ICP – intracranial pressure, MAP – mean arterial pressure, etCO2 – end tidal carbon dioxide, pCO2 – partial carbon dioxide pressure, CTRL – control, AZE – acetazolamide. Data are shown as mean ± SD. *; P < 0.05, **; P < 0.01, ***; P < 0.001, ns; not significant.