Fig. 7

Schematic representation of the proteins involved in the interferon signaling induced in antiviral response that are significantly predicted by Ingenuity Pathway Analysis to be affected by the flow in hCMEC/D3 cells. Analysis gives the common responses to shear stress exposure at both 5 and 10 dyn.cm⁻² compared to the static culture. Relative changes in protein levels are depicted by graduated shades of color coding: red, up; green, down; white, no change or not applicable; orange: activation predicted; blue: inhibition predicted. Proteins in surrounded of purple are modified only at 10 dyn.cm⁻² vs static; and those surrounded of pink are modified only at 5 dyn.cm⁻² vs static