White matter changes should not exclude patients with idiopathic normal pressure hydrocephalus from shunt surgery

Table 3 Linear regression with shunt surgery outcome (delta scores) as dependent variables and radiological volumes as independent variables

Delta score	Volume	Unadjusted		Adjusted		n
		B	P-value	B	P-value
Delta total iNPH score	PVH	− 1.260	0.0269*	− 1.173	0.0309*	253
	DWMH	− 0.816	0.0899	− 0.761	0.0896	253
	Lateral ventricles	1.752	0.501	4.002	0.229	253
Delta balance score	PVH	− 0.557	0.357	− 0.365	0.518	238
	DWMH	− 0.481	0.35	− 0.086	0.856	238
	Lateral ventricles	0.873	0.756	3.911	0.259	238
Delta continence score	PVH	0.048	0.959	− 0.020	0.982	235
	DWMH	− 0.241	0.755	− 0.183	0.809	235
	Lateral ventricles	4.600	0.282	13.337	0.0175*	235
Delta gait score	PVH	− 2.148	0.00352**	− 2.068	0.00314**	252
	DWMH	− 1.071	0.0861	− 1.073	0.0636	252
	Lateral ventricles	1.172	0.729	0.157	0.971	252
Delta cognitive score	PVH	− 0.042	0.95	0.047	0.944	95
	DWMH	− 0.632	0.263	− 0.659	0.231	95
	Lateral ventricles	0.564	0.86	0.690	0.875	95
Delta MMSE score	PVH	− 0.201	0.0703	− 0.146	0.196	241
	DWMH	− 0.128	0.167	− 0.059	0.519	241
	Lateral ventricles	1.242	0.0138*	1.283	0.063	241

Data are adjusted for age, gender, time between preoperative evaluation and surgery, preoperative total iNPH scale score, Evans’ index, and DESH
iNPH idiopathic normal pressure hydrocephalus, DESH disproportionately enlarged subarachnoid space hydrocephalus, B unstandardized regression coefficient, PVH periventricular hyperintensities, DWMH deep white matter hyperintensities, MMSE mini-mental state examination. Bold values are significant, * < 0.05, ** < 0.01

ISSN: 2045-8118