Table 2 Region/cell-specific expression of ADCYs in the CNS

ADCY1

Piriform cortex^#, CA1-CA2 of hippocampus^#, dentate gyrus^#, striatum^#, amygdala^{^}, thalamus^#, and cerebellum^#, cerebral cortex^{^}, and olfactory bulb layers^*

Neurons^#, oligodendrocytes^{^}, microglia^{^}, astrocytes^{^}, fibroblasts^* and endothelial cells^*

ADCY2

Piriform cortex^#, CA1 of hippocampus^#, dentate gyrus^#, striatum^#, CA2-CA3 of hippocampus^{^}, thalamus^{^}, hypothalamus^{^}, olfactory bulb layers^{^}, cerebral cortex^{^}, amygdala^*, and cerebellum^*

Neurons^#, astrocytes^#, fibroblasts^#, smooth muscle cells^#, oligodendrocytes^{^}, microglia^*, endothelial cells^*, pericytes^*

ADCY3

CA1-CA3 of hippocampus^#, dentate gyrus^#, cerebral cortex^{^}, striatum^{^}, amygdala^{^}, thalamus^{^}, hypothalamus^{^}, cerebellum^{^}, olfactory bulb layers^*, piriform cortex^*, and choroid plexus

Neurons^#, astrocytes^#, fibroblasts^#, pericytes^#, oligodendrocytes^{^}, smooth muscle cells^*, microglia^*, endothelial cells^*, and choroid plexus epithelial cells

ADCY4

Hippocampus^* and olfactory epithelium^*

Endothelial cells^#, neurons^*, astrocytes^*, fibroblasts^*, smooth muscle cells^*, oligodendrocytes^*, microglia^*, and pericytes^*

ADCY5

Striatum^#, hypothalamus^{^}, olfactory bulb layers^{^}, cerebral cortex^*, piriform cortex^*, amygdala^*, CA1-CA3 of hippocampus^*, dentate gyrus^*, and thalamus^*

Neurons^#, oligodendrocytes^#, fibroblasts^#, smooth muscle cells^#, astrocytes^*, microglia^*, endothelial cells^*, and pericytes^*

ADCY6

Piriform cortex^#, amygdala^#, CA1-CA3 of hippocampus^#, dentate gyrus^#, hypothalamus^#, cerebellum^#, choroid plexus^#, olfactory bulb layers^{^}, cerebral cortex^{^}, striatum^{^}, and thalamus^{^}

Neurons^#, astrocytes^#, fibroblasts^#, smooth muscle cells^#, oligodendrocytes^#, endothelial cells^#, pericytes^#, and microglia^*

ADCY7

Thalamus^{^}, and hypothalamus^{^}, cerebral cortex^*, amygdala^*, corpus callosum^*, cerebellum^*, and olfactory system^*

Fibroblasts^#, smooth muscle cells^#, microglia^#, neurons^*, astrocytes^*, oligodendrocytes^*, endothelial cells^*, and pericytes^*

ADCY8

Piriform cortex^#, CA1-CA2 of hippocampus^#, dentate gyrus^#, thalamus^#, hypothalamus^#, cerebellum^#, olfactory bulb^#, cerebral cortex^*, and amygdala^*

Neurons^#, astrocytes^#, fibroblasts^*, smooth muscle cells^*, oligodendrocytes^*, microglia^*, and endothelial cells^*

ADCY9

Olfactory bulb^#, cerebral cortex^#, piriform cortex^#, CA1-CA3 of hippocampus^#, dentate gyrus^#, cerebellum^#, amygdala^{^}, thalamus^*, and hypothalamus^*

Neurons^#, astrocytes^#, fibroblasts^#, smooth muscle cells^#, oligodendrocytes^#, microglia^#, endothelial cells^#, and pericytes^#

ADCY10

Visual cortex^*, hippocampus^*, and cerebellum^*, and choroid plexus

Neurons^*, astrocytes^*, fibroblasts^*, smooth muscle cells^*, oligodendrocytes^*, microglia^*, endothelial cells^*, pericytes^*, and choroid plexus epithelial cells