Table 2 vCSF-SLOPE and tracer binding
From: Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Group | vCSF-SLOPETHK5351 | vCSF-SLOPEPiB | 11C-PiB GM SUVr 50–70 min | 11C-PiB GM SUVr 10–30 min | 18F-THK5351 GM SUVr 10–30 min | 18F-THK5351 GM SUVr 10–30 min |
|---|---|---|---|---|---|---|
NL | 0.11 (0.02) | 0.11 (0.01) | 1.28 (0.17) | 1.02 (0.05) | 1.30 (0.12) | 1.41 (0.20) |
AD | 0.09 (0.02) | 0.08 (0.02) | 1.88 (0.30) | 1.25 (0.12) | 1.37 (0.10) | 1.63 (0.11) |
Diff. from normal | − 18%, p < 0.01 | − 27%, p < 0.01 | 46%, p < 0.01 | 22%, p < 0.01 | 5%, NS | 16%, p < 0.05 |