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Table 2 Physicochemical characterization of NLC used in all the experimental studies (one batch)

From: Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures

Formulation

Mean size after Lyophi. (nm)

PDI

Zeta potential (mV)

EE (%)

CS-NLC-DiD*

 

≈100

TAT-CS-NLC-DiD(*)

≈100

Miglyol-NLC

119.1 ± 18.0

0.323 ± 0.039

17.4 ± 0.8

–

DHAH-NLC

105.4 ± 25.6

0.400 ± 0.032

20.9 ± 0.5

–

DHAH-NLC-GDNF

257.1 ± 3.5

0.338 ± 0.022

18.0 ± 0.4

82.01 ± 1.67

DHAH-NLC-VEGF

264.1 ± 16.0

0.471 ± 0.076

20.5 ± 0.8

88.74 ± 0.37

  1. *The presence of a fluorescent dye (DiD) makes it impossible to measure accurately the size, PDI and zeta potential of these two formulations
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Fluids and Barriers of the CNS

ISSN: 2045-8118