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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Dual effect of TAT functionalized DHAH lipid nanoparticles with neurotrophic factors in human BBB and microglia cultures

Fig. 3

NLC modified transport across BMCEs A TAT-CS-NLC-DiD successfully penetrate the BMEC monolayer as opposed to the CS-NLC-DiD. (Data are means ± SEM of three independent experiments, p < 0.01 **, One-sample t-test analysis) B Representative images of the BMEC monolayer after treatment with our NPs. Blue shows the nuclei stained with DAPI, green shows the tight junctions stained with ZO-1, whereas the NLCs are shown in magenta (incorporated DiD). TAT-CS-NLC-DiD could be detected in our cell monolayer, while CS-NLC-DiD were not detectable. The images show the maximum intensity projection of a Z stack. Scale bar 50 µm

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Fluids and Barriers of the CNS

ISSN: 2045-8118