Fig. 1From: The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatmentsPathophysiology of brain edema during subarachnoid hemorrhage. Intracranial pressure (ICP), one of the immediate responses to subarachnoid hemorrhage (SAH), can cause both vasogenic and cytotoxic edema. Cytotoxic edema, characterized by cell swelling and apoptosis of endothelial cells (ECs), results in disruption of BBB, which ends up with an abnormal accumulation of fluid in brain cells and, eventually, vasogenic edema. Vasogenic edema leads to increased cerebral blood flow (CBF), ATP depletion, and disturbances in cell membrane transport systems leading to abnormal accumulation of fluid in brain cells, which can cause cytotoxic edemaBack to article page