Fig. 5
The effects of l- and d-ornithine (l-orn and d-orn, 20 mM, 24 h) on the permeability of the triple BBB co-culture model. a Schematic drawing of the triple BBB co-culture model assembled from primary rat endothelial cells, brain pericytes and astroglia cells. b Transendothelial electrical resistance (TEER) measurement across the model, n = 3. c Permeability for sodium fluorescein (376 Da), n = 4–5; d Permeability for Evans blue-labelled albumin (67 kDa), n = 4–5. Control groups (C) received culture medium. Values presented are means ± SEM. Statistical analysis: one-way Anova followed by Bonferroni post-test, *, p < 0.05; ***, p < 0.001. Permeability is expressed as endothelial permeability coefficient (Pe)