Fig. 3

Administration of Met-R decreased brain edema and improved neurological deficits at 24 h and 72 h after ICH in mice. A Modified Garcia test, B Limb placement test, C Corner turn test, and D Brain edema at 24 h following surgery in sham, vehicle-treated ICH, and Met-R (0.15, 0.5, and 1.5 μg/kg/day)-treated ICH groups. E Modified Garcia test, F Limb placement test, G Corner turn test and H Brain edema at 72 h following surgery in sham, vehicle-treated ICH, and Met-R (0.5 μg/kg/day)-treated ICH groups. Brain sections were divided into five parts: Ipsi-BG (ipsilateral basal ganglia), Cont-BG (contralateral basal ganglia), Ipsi-CX (ipsilateral cortex), Cont-CX (contralateral cortex), and Cerebel (cerebellum). Data were expressed as mean ± SD or median with range. ^**p < 0.01, ^***p < 0.001 vs. sham; ^##p < 0.01, ^###p < 0.001 vs. vehicle; n = 6/group