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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

Fig. 1

Experimental design of animal study. Experiment 1: Time course study and cellular localization. Experiment 2: Effects of Met-R on short-term outcomes including neurobehavior and brain edema at 24 and 72 h after ICH. Experiment 3: Long-term outcome study up to 25 days after ICH. Experiment 4: BBB permeability and hematoma volume at 24 after ICH. Experiment 5: Mechanism study to elucidate the role of Rac1 as a downstream mediator of CCR1. Experiment 6: Mechanism study to elucidate the rCCL5-mediated activation of CCR1 in naïve animals. ICH: intracerebral hemorrhage; Met-R: Met-RANTES; CCR1: C–C chemokine receptor type 1; rCCL5: recombinant chemokine ligand 5; WB: Western blot; IF: immunofluorescence staining; i.c.v.: intracerebroventricular

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Fluids and Barriers of the CNS

ISSN: 2045-8118