Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Table 1 Drug concentrations in the cerebrospinal fluid

Drug	Molecular size (Da)	Drug concentration in the CSF (%)
Drug	Molecular size (Da)	FSW	Control
Penicillin G	334	13.63 ± 4.51	2.62 ± 1.38	**
Doxorubicin	544	59.09 ± 11.18	6.92 ± 4.67	**
Evans blue [C]	67,000	0.39 ± 0.06	0.04 ± 0.04	**
FITC-Dextran	70,000	1.41 ± 0.37	0.16 ± 0.18	**
Bevacizumab	149,000	33.34 ± 10.44	14.6 ± 5.79	*
FITC-Dextran	500,000	2.44 ± 0.78	0.11 ± 0.39	*

* and **, p < 0.05 and 0.01, respectively, vs. control, in one-way ANOVA with the Tukey post hoc test (n = 5)
Sampling time: at 3 h after the FSW-treatment; FSW-position: C
Unit: %, CSF/blood drug concentration

ISSN: 2045-8118