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Table 1 Drug concentrations in the cerebrospinal fluid

From: Facilitating drug delivery in the central nervous system by opening the blood-cerebrospinal fluid barrier with a single low energy shockwave pulse

Drug Molecular size (Da) Drug concentration in the CSF (%)
FSW Control  
Penicillin G 334 13.63 ± 4.51 2.62 ± 1.38 **
Doxorubicin 544 59.09 ± 11.18 6.92 ± 4.67 **
Evans blue [C] 67,000 0.39 ± 0.06 0.04 ± 0.04 **
FITC-Dextran 70,000 1.41 ± 0.37 0.16 ± 0.18 **
Bevacizumab 149,000 33.34 ± 10.44 14.6 ± 5.79 *
FITC-Dextran 500,000 2.44 ± 0.78 0.11 ± 0.39 *
  1. * and **, p < 0.05 and 0.01, respectively, vs. control, in one-way ANOVA with the Tukey post hoc test (n = 5)
  2. Sampling time: at 3 h after the FSW-treatment; FSW-position: C
  3. Unit: %, CSF/blood drug concentration