The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients

Sundström, Nina; Rydja, Johanna; Virhammar, Johan; Kollén, Lena; Lundin, Fredrik; Tullberg, Mats

doi:10.1186/s12987-021-00298-5

Fluids and Barriers of the CNS

Table 2 Preoperative, post-operative and change in TUG time and steps pre-/post-operatively

From: The timed up and go test in idiopathic normal pressure hydrocephalus: a Nationwide Study of 1300 patients

Group	Age group	N Preop/post-op/improvement	Preoperative values		Post-operative values		Improvement (%)
Group	Age group	N Preop/post-op/improvement	Median [Q1, Q3]	Mean [SD]	Median [Q1, Q3]	Mean [SD]	Median [Q1, Q3]	Mean [SD]
Stratified by sex
TUG_time total	All	1249	19.0 [14.0, 26.0]	22.2 [12.1]	14.0 [11.0, 20.0]	16.9 [9.2]	21.7 [2.9, 36.8]	17.6 [32.5]
TUG_time women	All	505	20.0 [15.0, 28.5]	23.6 [12.2]	16.0 [12.0, 21.0]	17.7 [8.8]	22.2 [4.1, 38.5]	18.6 [31.7]
TUG_time men	All	744	18.0 [14.0, 25.0]	21.2 [11.9]	13.5 [11.0, 19.0]	16.4 [9.4]	21.5 [2.6, 36.4]	17.0 [33.1]
TUG_steps total	All	1226/1243/1227	23.0 [18.0, 30.0]	26.0 [11.4]	19.0 [15.0, 25.0]	21.1 [8.9]	16.7 [0.0, 31.0]	14.7 [26.9]
TUG_steps women	All	496/503/495	24.0 [19.0, 32.0]	26.8 [10.7]	20.0 [16.0, 26.0]	21.9 [7.9]	16.7 [0.0, 30.0]	14.3 [25.1]
TUG_steps men	All	733/740/732	22.0 [18.0, 29.0]	25.5 [11.8]	18.0 [15.0, 24.0]	20.6 [9.4]	17.2 [3.9, 31.1]	15.0 [28.0]
10MWT_time total	All	858/842/796	14.5 [11.3, 19.0]	16.8 [9.8]	11.4 [9.0, 15.0]	13.1 [5.9]	17.2 [0.0, 32.9]	15.5 [29.4]
10MWT_time women	All	344/339/319	15.5 [12.9, 20.9]	18.1 [10.6]	12.3 [10.0, 16.0]	13.9 [6.2]	18.2 [0.0, 34.5]	17.1 [27.1]
10MWT_time men	All	514/503/477	14.0 [11.0, 18.0]	15.9 [9.2]	11.0 [9.0, 14.5]	12.6 [5.6]	16.7 [0.0, 31.3]	14.5 [30.8]
Stratified by age
TUG_time total	< 70	259	17.0 [13.0, 24.0]	19.6 [9.9]	12.0 [9.5, 16.0]	14.2 [7.6]	25.0 [9.1, 40.8]	22.7 [31.3]
TUG_time total	70 ≤ x < 80	759	18.5 [14.0, 25.4]	22.0 [12.4]	14.0 [11.0, 19.0]	16.7 [9.5]	21.9 [3.7, 36.4]	17.6 [32.6]
TUG_time total	≥ 80	231	23.0 [17.0, 30.0]	25.6 [12.5]	19.0 [14.7, 24.0]	20.7 [8.7]	14.3 [0.0, 32.2]	11.9 [32.9]
TUG_steps total	< 70	254/258/254	21.0 [16.8, 28.0]	23.7 [10.3]	16.5 [14.0, 21.0]	18.5 [7.5]	20.0 [5.9, 31.6]	17.0 [26.6]
TUG_steps total	70 ≤ x < 80	746/756/741	23.0 [18.0, 30.0]	25.8 [11.2]	19.0 [15.0, 24.0]	20.9 [8.7]	17.4 [3.5, 31.3]	14.8 [26.7]
TUG_steps total	≥ 80	229/229/226	26.0 [21.0, 33.0]	29.4 [12.4]	23.0 [18.0, 29.0]	24.9 [9.4]	11.3 [-3.4, 26.7]	10.4 [25.3]
Outliers
TUG_time outliers	All	51	91.0 [58.0, 122.0]	96.7 [54.3]	40.0 [25.8, 90.0]	62.2 [52.4]	53.1 [− 47.1, 75.0]	− 3.4 [140.1]
TUG_steps outliers	All	49/51/49	82.0 [59.5, 97.5]	85.2 [46.2]	40.0 [29.0, 68.0]	52.9 [30.5]	44.0 [− 4.0, 66.3]	22.1 [61.2]
TUG_time all including outliers	All	1300	19.0 [14.0, 27.3]	25.1 [21.5]	14.8 [11.0, 21.0]	18.7 [16.3]	22.2 [2.5, 38.2]	16.6 [43.2]
TUG_steps all including outliers	All	1277/1294/1273	23.0 [18.0, 31.0]	28.2 [18.3]	19.0 [15.0, 26.0]	22.4 [12.3]	17.2 [0.0, 31.6]	14.5 [29.5]

Pre- and post-operative values of TUG_time, TUG_steps and 10MWT_time in all patients and by sex and age groups. All post-operative changes were significantly different (Related samples Wilcoxon Signed Rank test, p < 0.001), women performed worse than men in both TUG and 10MWT_time pre- as well as post-operatively (Independent samples Mann–Whitney U test, p < 0.001) and the younger age groups performed better on the TUG test than the older ones (Independent samples Kruskal–Wallis test and Independent samples Mann–Whitney U test, p < 0.001)

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ISSN: 2045-8118

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