Skip to main content
Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 7

WISP1 activation abolished the effects of FZD7 knockdown on the expression of downstream TJPs. A Representative western blot bands at 24 h after ICH. B–I Densitometric quantification of FZD7, Dvl, β-Catenin, phospho-β-Catenin, WISP1, ZO-1, VE-Cadherin, and Claudin-5 in the ipsilateral hemisphere at 24 h after ICH. n = 6 per group; KO Ctrl: control CRISPR KO; FZD7 KO: Frizzled-7 CRISPR KO; ACT Ctrl: control CRISPR activation; WISP1 ACT: WISP1 CRISPR activation. Data was represented as mean ± SD. FZD7: Frizzled-7; WISP1: WNT1-inducible signaling pathway protein 1; TJPs: tight junction proteins; ICH: intracerebral hemorrhage. *p < 0.05 and **p < 0.01 vs. sham, #p < 0.05 and ##p < 0.01 vs. ICH + ACT Ctrl, &p < 0.05 and &&p < 0.01 vs. ICH + FZD7 ACT + WISP1 KO; One-way ANOVA, Tukey’s post hoc test

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118