SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Table 3 Summary of SCO-spondin domains and possible CSF binding partners on the basis of described interactions of these domains in other proteins

Domain	Protein	Ligand (soluble or cell receptor)	References
EMI	Periostin, Emilin-3	Itself, TGFβ1	[118, 119, 210]
EMI	SCO-spondin	Itself	[33]
LDLrA	LDLr	Lipoproteins (Apo B and E)	[102]
	VLDLr	Apo E, Reelin	[102, 103]
	ApoER2	ApoE, Reelin, F-spondin, APP	[102, 211]
	Megalin/LRP2	ApoB, ApoE, carrier proteins for lipophilic vitamins, proteases and inhibitors, Apo J	[102, 212]
	LRP-1	ApoE, APP, protease/inhibitor complex, Thrombospondin-1: β Amyloid peptide, TGFβ, BMP4 MMP2 and 9, Insulin growth factor-1	[102, 213,214,215,216,217]
	LRP6	Wnts	[102, 218]
	SCO-spondin	LDL	[81]
vWFC	Crossveinless	BMP2	[219]
	TSP-1	BMP2,4	[85]
	CCN2	BMP2, TGFβ	[82]
	CCN1	BMPs, Integrin αv β3	[220]
TSR	Thrombospondin-1	MMP-2, CD36, Integrin β1, TGF-β, FGF-2	[74, 221,222,223,224,225]
	CCN Family	Integrin TGFB LRP-1	[17]
	SCO-spondin	Integrin β1	[75]
CTCK	CCN3	Notch1	[226]
	CCN2	HSPG and Integrins α_v β₃	[95]
	CCN1	Wnts and LRP6	[96, 97]
	vWF	Itself	[123]
vWFD	vWF	Itself	[123]
vWFD	Gel forming mucins	Itself	[125]
EGF-like	Neuroregulin	Integrins α_v β₃	[227]
	Thrombospondin-1	FGF-1	[110]
	Tenascin	EGF receptor	[111]

ISSN: 2045-8118