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Table 3 Summary of SCO-spondin domains and possible CSF binding partners on the basis of described interactions of these domains in other proteins

From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Domain Protein Ligand (soluble or cell receptor) References
EMI Periostin, Emilin-3 Itself, TGFβ1 [118, 119, 210]
SCO-spondin Itself [33]
LDLrA LDLr Lipoproteins (Apo B and E) [102]
VLDLr Apo E, Reelin [102, 103]
ApoER2 ApoE, Reelin, F-spondin, APP [102, 211]
Megalin/LRP2 ApoB, ApoE, carrier proteins for lipophilic vitamins, proteases and inhibitors, Apo J [102, 212]
LRP-1 ApoE, APP, protease/inhibitor complex, Thrombospondin-1: β Amyloid peptide, TGFβ, BMP4 MMP2 and 9, Insulin growth factor-1 [102, 213,214,215,216,217]
LRP6 Wnts [102, 218]
SCO-spondin LDL [81]
vWFC Crossveinless BMP2 [219]
TSP-1 BMP2,4 [85]
CCN2 BMP2, TGFβ [82]
CCN1 BMPs, Integrin αv β3 [220]
TSR Thrombospondin-1 MMP-2, CD36, Integrin β1, TGF-β, FGF-2 [74, 221,222,223,224,225]
CCN Family Integrin TGFB LRP-1 [17]
SCO-spondin Integrin β1 [75]
CTCK CCN3 Notch1 [226]
CCN2 HSPG and Integrins αv β3 [95]
CCN1 Wnts and LRP6 [96, 97]
vWF Itself [123]
vWFD vWF Itself [123]
Gel forming mucins Itself [125]
EGF-like Neuroregulin Integrins αv β3 [227]
Thrombospondin-1 FGF-1 [110]
Tenascin EGF receptor [111]