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Table 2 Effect of inhibition of individual eCSF factors on the differentiation and proliferation of neuroepithelium

From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

CSF component Inhibition approach Inhibition versus control References
Lipoproteins Chick mesencephalic explants cultured in eCSF depleted of lipoproteins 80% lower neurodifferentiation
90% lower proliferation
[106]
FGF2 Addition of anti-FGF2 to chick mesencephalic explants cultured in eCSF 40% lower neurodifferentiation
60% lower proliferation
[195]
SCO-spondin Addition of anti-SCO-spondin to chick mesencephalic explants cultured in eCSF 75% lower neurodifferentiation
275% higher proliferation
[24, 81]
Retinoic acid/retinol binding protein (RBP) Addition of anti-RBP to chick mesencephalic explants cultured in eCSF 40% lower neurodifferentiation [203]
  1. The summation of individual effects is higher than 100%, revealing that CSF factors have interactive effects