Skip to main content

Table 2 Effect of inhibition of individual eCSF factors on the differentiation and proliferation of neuroepithelium

From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

CSF component

Inhibition approach

Inhibition versus control

References

Lipoproteins

Chick mesencephalic explants cultured in eCSF depleted of lipoproteins

80% lower neurodifferentiation

90% lower proliferation

[106]

FGF2

Addition of anti-FGF2 to chick mesencephalic explants cultured in eCSF

40% lower neurodifferentiation

60% lower proliferation

[195]

SCO-spondin

Addition of anti-SCO-spondin to chick mesencephalic explants cultured in eCSF

75% lower neurodifferentiation

275% higher proliferation

[24, 81]

Retinoic acid/retinol binding protein (RBP)

Addition of anti-RBP to chick mesencephalic explants cultured in eCSF

40% lower neurodifferentiation

[203]

  1. The summation of individual effects is higher than 100%, revealing that CSF factors have interactive effects
Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118