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Table 1 Relevant CSF molecules and their ascribed functions

From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

CSF component Function References
Amyloid-β peptide Neurodegeneration [190]
BMPs Differentiation, proliferation, and survival of neuroepithelium [6, 191,192,193]
Clusterin (ApoJ) Neurodegeneration [194]
Epithelial growth factor Proliferation and differentiation of neuroepithelium [78]
Fibroblast growth factor 2 Proliferation, differentiation, and survival of neuroepithelium [78, 195]
Insulin growth factor 1 Differentiation, proliferation, and survival of neuroepithelium. Adult neurogenesis, synaptogenesis [191, 196,197,198]
Lipoproteins (LDL, VLDL, HDL) Proliferation and differentiation of neuroepithelium [106, 199]
Monoamines (Epinephrine, norepinephrine, serotonin,
L-Dopa)
Neurotransmission [200]
Nerve growth factor Cell proliferation and survival of neuroepithelium [201]
Reelin Brain development [202]
Retinoic acid Differentiation of neuroepithelium [203]
Shh Differentiation, proliferation, and survival of neuroepithelium [204]
SCO-spondin Differentiation, proliferation, and survival of neuroepithelium [24, 25, 205]
Transforming growth factor β1–β2 Regeneration and pathological processes [206, 207]
Wnts (Wnt4, 5A) Differentiation and proliferation of neuroepithelium, brain morphogenesis [109, 191, 208, 209]
  1. The molecules listed were chosen because they bind to proteins with similar domains as those present in SCO-spondin