SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity

Table 1 Relevant CSF molecules and their ascribed functions

CSF component	Function	References
Amyloid-β peptide	Neurodegeneration	[190]
BMPs	Differentiation, proliferation, and survival of neuroepithelium	[6, 191,192,193]
Clusterin (ApoJ)	Neurodegeneration	[194]
Epithelial growth factor	Proliferation and differentiation of neuroepithelium	[78]
Fibroblast growth factor 2	Proliferation, differentiation, and survival of neuroepithelium	[78, 195]
Insulin growth factor 1	Differentiation, proliferation, and survival of neuroepithelium. Adult neurogenesis, synaptogenesis	[191, 196,197,198]
Lipoproteins (LDL, VLDL, HDL)	Proliferation and differentiation of neuroepithelium	[106, 199]
Monoamines (Epinephrine, norepinephrine, serotonin, L-Dopa)	Neurotransmission	[200]
Nerve growth factor	Cell proliferation and survival of neuroepithelium	[201]
Reelin	Brain development	[202]
Retinoic acid	Differentiation of neuroepithelium	[203]
Shh	Differentiation, proliferation, and survival of neuroepithelium	[204]
SCO-spondin	Differentiation, proliferation, and survival of neuroepithelium	[24, 25, 205]
Transforming growth factor β1–β2	Regeneration and pathological processes	[206, 207]
Wnts (Wnt4, 5A)	Differentiation and proliferation of neuroepithelium, brain morphogenesis	[109, 191, 208, 209]

The molecules listed were chosen because they bind to proteins with similar domains as those present in SCO-spondin

ISSN: 2045-8118