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Table 2 Changes in model output parameters as ICP rises from baseline to 30 mmHg under four conditions

From: Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema

  ROUT RVEN RBF RBBB
Total brain volume (\(ml\))  + 16  − 62  + 94  + 94
Ventricular volume (\(ml\))  + 20  + 133  − 25  − 25
Subarachnoid space volume (\(ml\))  + 10  − 25  − 24  − 24
Cerebral blood volume (\(ml\))  − 41  − 41  − 40  − 40
CBF (\({ml 100 gr}^{-1}\) \({min}^{-1}\))  − 26  − 26  − 26  − 26
  1. The Table describes the output parameters under four input conditions: increased resistance to CSF absorption, increased resistance to ventricular CSF flow, increased resistance to bulk flow of ISF, and breakdown of the BBB. ROUT: resistance to cerebrospinal fluid (CSF) outflow; RVEN: resistance to CSF flow in the ventricular system; RBF: resistance to bulk flow of cerebral interstitial fluid; RBBB: resistance to flow of fluid across the blood–brain barrier; CBF: cerebral blood flow