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Table 2 Changes in model output parameters as ICP rises from baseline to 30 mmHg under four conditions

From: Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema

 

ROUT

RVEN

RBF

RBBB

Total brain volume (\(ml\))

 + 16

 − 62

 + 94

 + 94

Ventricular volume (\(ml\))

 + 20

 + 133

 − 25

 − 25

Subarachnoid space volume (\(ml\))

 + 10

 − 25

 − 24

 − 24

Cerebral blood volume (\(ml\))

 − 41

 − 41

 − 40

 − 40

CBF (\({ml 100 gr}^{-1}\) \({min}^{-1}\))

 − 26

 − 26

 − 26

 − 26

  1. The Table describes the output parameters under four input conditions: increased resistance to CSF absorption, increased resistance to ventricular CSF flow, increased resistance to bulk flow of ISF, and breakdown of the BBB. ROUT: resistance to cerebrospinal fluid (CSF) outflow; RVEN: resistance to CSF flow in the ventricular system; RBF: resistance to bulk flow of cerebral interstitial fluid; RBBB: resistance to flow of fluid across the blood–brain barrier; CBF: cerebral blood flow