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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging

Fig. 6

Correlations between FW, AFD with FW-corrected DTI metrics in each subregion of WMHs. A FW correlated with AFD in FWq3 and FWq4 (both p < 0.001), and marginally correlated with AFD in FWq2 (p = 0.006). B FW correlated with MDt in FWq1, FWq2 and FWq3 (all p < 0.001). CE AFD correlated with FAt, ADt and RDt in each subregion of WMHs (all p < 0.001). The MDt, ADt and RDt values are in units of × 10−3 mm2/s. *Indicates Bonferroni corrected p < 0.05; NS. indicates not significant. FW free water, AFD apparent fiber density, DTI diffusion tensor imaging, WMHs white matter hyperintensities, MDt tissue compartment mean diffusivity, FAt tissue compartment fractional anisotropy; ADt tissue compartment axial diffusivity, RDt tissue compartment radial diffusivity, FWq1-4 four subregions of WMHs split by FW quartiles

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