Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 8 Overexpressed biological processes related to glutamate metabolism

GO-slim biological process Category	Child category	Child category	Child category	Child category	Child category	Child category	Number of genes process	Number of genes overexpressed	Expected value	Fold enrichment	P-value
Small molecule metabolic process (GO:0044281)							587	11	4.11	2.67	3.02E-03
	Organic acid metabolic process (GO:0006082)						355	7	2.49	2.81	1.31E-02
		Oxoacid metabolic process (GO:0043436)					342	7	2.40	2.92	1.08E-02
			Carboxylic acid metabolic process (GO:0019752)				331	7	2.32	3.02	9.19E-03
				Cellular amino acid metabolic process (GO:0006520)			123	4	0.86	4.64	1.14E-02
					Alpha-amino acid metabolic process (GO:1901605)		77	4	0.54	7.41	2.24E-03
						Glutamate metabolic process (GO:0006536)	4	2	0.3	71.36	3.83E-04

Identification of biological processes related to overexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO Slim biological process annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice

ISSN: 2045-8118