Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 5 Overexpressed biological processes related to metabolism

GO-slim biological process category	Child category	Child category	Number of genes process	Number of genes overexpressed	Expected value	Fold enrichment	P-value
Cellular metabolic process (GO:0044237)			4357	40	30.53	1.31	3.83E-02
	Organonitrogen compound metabolic process (GO:1901564)		2567	28	17.71	1.58	9.64E-03
	Ammonium ion metabolic process (GO:0097164)		36	2	0.25	7.03	2.68E-02
Biosynthetic process (GO:0009058)			2006	22	14.06	1.57	2.38E-02
	Organic substance biosynthetic process (GO:1901576)		1986	22	13.91	1.58	2.15E-02
		Organonitrogen compound biosynthetic process (GO:1901566)	589	18	4.13	4.36	2.09E-07
		Organophosphate biosynthetic process (GO:0090407)	167	4	1.17	3.42	3.07E-02
	Phospholipid biosynthetic process (GO:0008654)		50	2	0.35	5.71	4.86E-02

Identification of biological processes related to overexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO Slim biological process annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice

ISSN: 2045-8118