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Table 5 Overexpressed biological processes related to metabolism

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

GO-slim biological process category Child category Child category Number of genes process Number of genes overexpressed Expected value Fold enrichment P-value
Cellular metabolic process (GO:0044237)    4357 40 30.53 1.31 3.83E-02
  Organonitrogen compound metabolic process (GO:1901564)   2567 28 17.71 1.58 9.64E-03
  Ammonium ion metabolic process
  36 2 0.25 7.03 2.68E-02
Biosynthetic process (GO:0009058)    2006 22 14.06 1.57 2.38E-02
  Organic substance biosynthetic process (GO:1901576)   1986 22 13.91 1.58 2.15E-02
   Organonitrogen compound biosynthetic process (GO:1901566) 589 18 4.13 4.36 2.09E-07
   Organophosphate biosynthetic process (GO:0090407) 167 4 1.17 3.42 3.07E-02
  Phospholipid biosynthetic process (GO:0008654)   50 2 0.35 5.71 4.86E-02
  1. Identification of biological processes related to overexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO Slim biological process annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice