Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 2 Underexpressed proteins implicated in the oligodendrocyte development

GO biological process class/child class	Gene name	Sum PEP score	Abundance ratio: (Sample) / (Control)	Abundance ratio P-value: (sample) / (control)
Oligodendrocyte development
	Fatty acid 2-hydroxylase* **	4.50	0.436	0.001
	Myelin-associated glycoprotein* **	177	0.341	2.22E-14
	Myelin proteolipid protein* **	42.4	0.324	1.33E-15
	Oligodendrocyte-myelin glycoprotein* **	28.9	0.667	0.027
	Tubulin polymerization-promoting protein * **	84	0.674	0.009
Glial development*
	Calcineurin subunit B type 1 **	62.58	0.72	0.047
	Protein NDRG1 **	35.04	0.666	0.043
	Tetraspanin-2 **	24.51	0.283	2.36E-11
Glial cell differentiation**
	2',3'-cyclic-nucleotide 3'-phosphodiesterase	485.39	0.401	1.16E-10
	Dual specificity mitogen-activated protein kinase kinase 1	203.85	0.661	0.006
	Receptor-type tyrosine-protein phosphatase zeta	196.06	0.726	0.039

Underexpressed proteins in the white matter of hyh mice implicated in the processes of oligodendrocyte development. *; **, Proteins in the classes are included in their respective child classes (see Table 1). The sum PEP score corresponds to the score calculated based on the posterior error probability (PEP) values of the peptide spectrum matches (PSM). The PEP indicates the probability that an observed PSM is a random event. Sum PEP score is calculated as the negative logarithms of the PEP values of the connected PSM

ISSN: 2045-8118