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Table 2 Underexpressed proteins implicated in the oligodendrocyte development

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

GO biological process class/child class Gene name Sum PEP score Abundance ratio: (Sample) / (Control) Abundance ratio P-value: (sample) / (control)
Oligodendrocyte development     
  Fatty acid 2-hydroxylase* ** 4.50 0.436 0.001
  Myelin-associated glycoprotein* ** 177 0.341 2.22E-14
  Myelin proteolipid protein* ** 42.4 0.324 1.33E-15
  Oligodendrocyte-myelin glycoprotein* ** 28.9 0.667 0.027
  Tubulin polymerization-promoting protein * ** 84 0.674 0.009
Glial development*     
  Calcineurin subunit B type 1 ** 62.58 0.72 0.047
  Protein NDRG1 ** 35.04 0.666 0.043
  Tetraspanin-2 ** 24.51 0.283 2.36E-11
Glial cell differentiation**     
  2',3'-cyclic-nucleotide 3'-phosphodiesterase 485.39 0.401 1.16E-10
  Dual specificity mitogen-activated protein kinase kinase 1 203.85 0.661 0.006
  Receptor-type tyrosine-protein phosphatase zeta 196.06 0.726 0.039
  1. Underexpressed proteins in the white matter of hyh mice implicated in the processes of oligodendrocyte development. *; **, Proteins in the classes are included in their respective child classes (see Table 1). The sum PEP score corresponds to the score calculated based on the posterior error probability (PEP) values of the peptide spectrum matches (PSM). The PEP indicates the probability that an observed PSM is a random event. Sum PEP score is calculated as the negative logarithms of the PEP values of the connected PSM