Fig. 3

Enhanced BBB permeability after Lrp1 CNS endothelial loss. A Immunoblotting and quantification for IgG in 3 µL cell- and blood-free CSF and B brain water content (calculated as [wet weight–dry weight] × 100/wet weight) in 20-month-old Lrp1^lox/lox; Slco1c1-CreER^T2 mice and Lrp1^lox/lox littermate controls. Mean ± SEM, n = 4 (in A) and 7 (in B) mice/group. Significance was determined by Student’s t test