Table 4 Estimated brain half-lives, AUCbrain(2–24 h) and observed brain Tmax, of %ID/g brain for [125I]mAb3D6-scFv8D3 and [125I]di-scFv3D6-8D3
From: Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Ligand | Half-lifebrain (h) | AUCbrain(2–24 h) | Tmax (h) |
|---|---|---|---|
[125I]mAb3D6-scFv8D3 | 8.1 (5.7–11.9) | 18.1 (16.0–20.1) | 8 |
[125I]di-scFv3D6-8D3 | 8.5 (6.8–11.0) | 8.8 (7.9–9.7) | 4 |