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Table 2 LigandTracer binding kinetic parameters of fitted data for [125I]mAb3D6-scFv8D3 and [125I]di-scFv3D6-8D3

From: Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Ligand

Model

Bmax1 (norm %)

ka1 (1/Ms)

kd1 (1/s)

KD1 (M)

[125I]mAb3D6-scFv8D3

1:1

98.73 ± 2.37

3.73 × 104 ± 7.75 × 103

1.91 × 10–6 ± 1.01 × 10–6

5.38 × 10–11 ± 2.92 × 10–11

[125I]di-scFv3D6-8D3

1:2

76.00 ± 3.66

2.02 × 104 ± 1.51 × 103

5.32 × 10–6 ± 3.96 × 10–7

2.65 × 10–10 ± 1.39 × 10–11

  

Bmax2 (norm %)

ka2 (1/Ms)

kd2 (1/s)

KD2 (M)

[125I]di-scFv3D6-8D3

1:2

73.14 ± 26.87

5.74 × 104 ± 2.92 × 104

3.61 × 10–4 ± 2.98 × 10–5

7.55 × 10–9 ± 3.78 × 10–9

  1. Association rate constant, ka; dissociation rate constant, kd; equilibrium dissociation constant, KD. Values are reported as mean ± standard deviation (n = 3)
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Fluids and Barriers of the CNS

ISSN: 2045-8118