Table 1 The total number of animals administered [125I]mAb3D6-scFv8D3 or [125I]di-scFv3D6-8D3, respectively, with the capillary depletion animals included in brackets
From: Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Euthanization time (h) post administration | No. of individuals (n) administered [125I]mAb3D6-scFv8D3 (capillary depletion animals) | No. of individuals (n) administered [125I]di-scFv3D6-8D3 (capillary depletion animals) |
|---|---|---|
2 | 6 (+ 4) | 4 (+ 4) |
4 | 4 | 4 |
6 | 6 (+ 4) | 4 (+ 4) |
8 | 7 | 4 |
10 | 6 | 4 |
12 | 6 | 4 |
16 | 5 | 4 |
24 | 6 (+ 4) | 4 (+ 4) |
Total | 46 (+ 12) | 32 (+ 12) |