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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Fig. 6

Increased transcytosis molecular signatures following CCH. a Heatmap of genes related to BBB TJ components in the Sham, 1 day, 3 day and 7 day groups. b Venn diagram of the number of all differentially expressed genes and BBB TJ components genes. All differentially genes represent different timepoints compared to the Sham group. c Volcano plot showing altered genes between the 3 day group and the Sham group. Light gray circles indicate differentially expressed genes. Significantly altered gene ontology (GO) terms are highlighted (red, exocytosis; light green, endocytosis; dark green, vesicle fusion). *selected genes of interest. d Heatmap of genes related to exocytosis, endocytosis and vesicle fusion in the Sham, 1 day, 3 day and 7 day groups. e Fragments per kilobase of transcript per million mapped reads (FPKM) of BBB TJ components related markers. n = 3 biologically independent samples per group; NS, not significant; **p < 0.01 and ***p < 0.001 compared to the Sham group; p values shown were derived from the DESeq2 statistical package

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Fluids and Barriers of the CNS

ISSN: 2045-8118