Fig. 7From: Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model Proposed mechanism. Based on our data presented here and our previously published data [22, 23], we propose that blocking Aβ-induced internalization protects P-gp from proteasomal degradation, which preserves P-gp protein expression and transport activity and helps to reduce Aβ brain levels in hAPP miceBack to article page