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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model

Fig. 6

NCZ lowers Aβ brain levels. a Western Blot showing hAβ40 and hAβ42 protein expression levels in brain tissue samples from vehicle-treated WT, vehicle-treated hAPP mice, hAPP mice dosed with 5 mg/kg NCZ and hAPP mice dosed with a combination of NCZ and CSA (5/25 mg/kg). β-Actin was used as protein loading control. b hAβ40 and c hAβ42 levels (pg/ml) in brain tissue samples from hAPP, hAPP-NCZ and hAPP-NCZ/CSA mice determined by ELISA. Statistics: ***, significantly lower than control, p < 0.001; **, significantly lower than control, p < 0.01

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Fluids and Barriers of the CNS

ISSN: 2045-8118