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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury

Fig. 1

HI brain injury is followed by time-dependent increases of tight-junction proteins CLDN5 and OCLN levels in cerebrospinal fluid and blood plasma. The levels of TJ-proteins CLDN5 and OCLN were measured using ELISA in plasma (a and c) and CSF (b and d) collected at 6 h (3 m, 4f) and 24 h (3 m, 4f) as well as 5 days post-HI (4 m, 3f). Data is expressed as a percentage of the median in the corresponding control-groups (dotted line at 100%) and columns depict mean value, n = 7–8 per group. Unpaired t-tests using original concentration values, * = p ≤ 0.05 or ** = p ≤ 0.01. m male, f  female. Bar graphs represent mean values

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Fluids and Barriers of the CNS

ISSN: 2045-8118