Longitudinal analysis of cerebral aqueduct flow measures: multiple sclerosis flow changes driven by brain atrophy

Table 2 Longitudinal analysis of phase contrast flow measures in both MS patients and HCs

AoS-derived measures	HCs (n = 13)			MS (n = 29)
AoS-derived measures	Baseline	Follow-up	BL to FU p-value	Baseline	Follow-up	BL to FU p-value
Vmean systolic peak (cm/s)	5.10 ± 2.31	4.89 ± 2.1	0.579	5.46 ± 2.16	5.43 ± 1.73	0.939
Vmean diastolic peak (cm/s)	3.75 ± 2.28	4.14 ± 2.37	0.204	4.22 ± 1.32	4.06 ± 1.20	0.415
Vmax systolic peak (cm/s)	9.16 ± 4.64	9.88 ± 5.03	0.177	9.85 ± 3.56	9.54 ± 2.97	0.53
Vmax diastolic peak (cm/s)	6.31 ± 3.19	7.61 ± 4.35	*0.035*	7.23 ± 2.00	7.86 ± 2.76	*0.037*
Average area (mm²)	2.62 ± 1.20	2.86 ± 1.26	0.19	3.12 ± 1.07	3.69 ± 1.55	*0.001**
Flow rate systolic peak (ml/min)	8.65 ± 6.05	8.78 ± 5.12	0.882	10.36 ± 5.53	12.16 ± 7.30	0.051
Flow rate diastolic peak (ml/min)	6.57 ± 5.59	7.55 ± 5.72	0.207	7.76 ± 3.51	9.33 ± 5.64	*0.023*
Net vol caudal (µl/beat)	37.74 ± 25.34	33.29 ± 19.41	0.334	46.93 ± 27.31	50.49 ± 34.4	0.391
Net vol cranial (µl/beat)	37.89 ± 36.75	38.92 ± 38.5	0.885	41.13 ± 23.56	45.86 ± 32.22	0.208

HCs healthy controls, MS multiple sclerosis, AoS Aqueduct of Sylvius, Vmean average velocity, Vmax maximal velocity, BL baseline, FU follow-up
All measures are shown as mean ± standard deviation. Paired repeated measure analysis was utilized. p-values lower than 0.05 were considered statistically significant and shown in bold italics where trending values are shown in italics
* Statistically significant after false discovery rate correction

ISSN: 2045-8118