Chemokine CXCL13 in serum, CSF and blood–CSF barrier function: evidence of compartment restriction

Table 1 Overview of CSF CXCL13-related categories

Groups	Categories		CSF CXCL13 (pg/ml)		NEG/N^Qalb	Serum CXCL13 (pg/ml		NEG/N^Qalb	Qcxcl13		NEG/N^Qalb	QAlb		NEG/N^Qalb
Groups	CSF CXCL13	n	Median	IQR	p-value	Median	IQR	p-value	Median	IQR	p-value	Median	IQR	p-value
NEG/N^Qalb	< 30	10	3.5	2–4.8		97	75–125		0.0	0.0–0.03		4.0	3.6–4.6
NEG/P^Qalb	< 30	12	7.5	3.3–20.5	ns	105	70–142	ns	0.1	0.0–0.2	ns	11.6	9.5–16.4	< 0.001
Low	30–99	14	61	41–77	< 0.01	98	52–186	ns	0.5	0.4–1.2	< 0.01	7.7	5.1–11.8	< 0.05
Medium	100–250	13	187	126–227	< 0.001	78	57–92	ns	2.6	1.4–3.2	< 0.001	11.7	4.6–16.2	< 0.001
High	> 250	20	> 505	378–505	< 0.001	113	76–272	ns	3.7	1.9–5.8	< 0.001	14.9	10.2–22.9	< 0.001

Significance testing and p-value refers to pair-wise comparisons with the NEG/N^QAlb category
IQR interquartile range, ns. not significant, QAlb albumin quotient, Qcxcl13 CXCL13 quotient (c_(CXCL13)CSF/c_(CXCL13)Serum), N^QAlb refers to normal BCSFB function, P^QAlb refers to BCSFB dysfunction

ISSN: 2045-8118