Fig. 2
From: Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
Effect of cytokine treatment on CSF secretion rate in female rats fed a C or HF diet. CSF secretion rates for a female controls and b female HF diet rats, were calculated from the dilution of Blue Dextran (Blue Dextran Cout/Cin) after steady-state was reached shown by the lines (solid lines no cytokines, dashed lines with cytokine). c CSF secretion rates were then calculated as a percentage change from each respective control (±SD) from female C (n = 3) and female HF (n = 3) rats for each respective cytokine treatment (n = 3). A two-way ANOVA was used to analyse the statistical significance. The significant results are shown following Sidak’s multiple comparison test a two-tailed equal variance t-test comparison each diet and sex variable. *P = ≤ 0.05, ***P=≤ 0.001. aCSF artificial cerebrospinal fluid, C control diet, HF high-fat diet, VCP ventriculo-cisternal perfusion, HC hydrocortisone, TNF-α tumour necrosis factor-α, IL-6 interleukin-6, IL-17 interleukin-17, CCL2 C–C motif chemokine ligand-2