Fig. 1
From: Cerebrospinal fluid dynamics modulation by diet and cytokines in rats
Control CSF secretion rates in male and female rats fed either a C or HF diet. Each VCP experiment was carried out by perfusing aCSF through both lateral ventricles of the rat brain. CSF secretion rates for a males and b females were calculated from the dilution of Blue Dextran (Blue Dextran Cout/Cin) after steady-state was reached shown by the lines (solid line control, dashed line high fat diet HF). c Samples from male C (n = 3), male HF (n = 4), female C (n = 3), female HF (n = 3) rats were averaged (±SD) and compared to one another. A two-way ANOVA was used to analyse the statistical significance. The significant results are shown following Sidak’s multiple comparison test a two-tailed equal variance t-test comparison each diet and sex variable. **P = ≤ 0.01, ***P = ≤ 0.001, ****P = ≤ 0.0001. aCSF artificial cerebrospinal fluid, C control diet, HF high-fat diet, VCP ventriculo-cisternal perfusion