Table 7 Top 10 regulated coculture enriched pathways at 24 h (top), 48 h (middle) and 96 h (bottom) for (A) the comparison of soloculture vs. coculture with human pericytes (CHP); and for (B) the comparison of soloculture vs. coculture with bovine pericytes (CBP)
A. | B. | ||||
|---|---|---|---|---|---|
24 h | 24 h | ||||
Pathway | Ratio | p-value | Pathway | Ratio | p-value |
Formation of translation preinitiation complex | 0.3 | 6.80E−05 | Regulation of cell division | 0.3 | 1.90E−05 |
Endoplasmic reticulum calcium ion homeostasis | 0.1 | 1.25E−03 | Endothelial cell migration | 0.3 | 2.20E−05 |
Porphyrin-containing compound biosynthetic process | 0.4 | 1.33E−03 | Sprouting angiogenesis | 0.4 | 2.80E−05 |
Ribonucleoprotein complex assembly | 0.4 | 2.31E−03 | Protein localization to organelle | 0.4 | 3.00E−05 |
Tetrapyrrole biosynthetic process | 0.4 | 3.38E−03 | Blood vessel endothelial cell migration | 0.4 | 3.50E−05 |
Cytoskeleton-dependent cytokinesis | 0.4 | 4.09E−03 | Chromosome segregation | 0.2 | 4.90E−05 |
Pigment biosynthetic process | 0.5 | 6.86E−03 | Epithelial cell migration | 0.5 | 1.10E−04 |
Negative regulation of centrosome duplication | 0.3 | 9.16E−03 | Ameboidal-type cell migration | 0.5 | 1.10E−04 |
Negative regulation of endoplasmic reticulum calcium ion concentration | 0.3 | 9.16E−03 | Viral life cycle | 0.4 | 1.30E−04 |
Negative regulation of centrosome cycle | 0.3 | 9.16E−03 | Tissue migration | 0.5 | 1.30E−04 |
48 h | 48 h | ||||
Notch signaling pathway | 0.5 | 4.60E−05 | Epithelial cell migration | 0.4 | 3.00E−04 |
Hyaluronan catabolic process | 0.1 | 4.50E−04 | Epithelium migration | 0.4 | 3.70E−04 |
Nuclear-transcribed mRNA poly(A) tail shortening | 0.4 | 5.90E−04 | Tissue migration | 0.4 | 3.70E−04 |
Formation of translation preinitiation complex | 0.2 | 9.50E−04 | Cell junction assembly | 0.4 | 4.20E−04 |
Response to cold | 0.3 | 2.90E−04 | Regulation of cell migration involved in sprouting angiogenesis | 0.3 | 5.20E−04 |
mRNA catabolic process | 0.5 | 3.19E−03 | Regulation of sprouting angiogenesis | 0.3 | 5.20E−04 |
Autonomic nervous system development | 0.2 | 4.49E−03 | Regulation of blood vessel endothelial cell migration | 0.2 | 5.30E−04 |
Polysaccharide biosynthetic process | 0.5 | 5.17E−03 | Carbohydrate biosynthetic process | 0.4 | 5.40E−04 |
Lipopolysaccharide metabolic process | 0.3 | 8.03E−03 | Blood vessel endothelial cell migration | 0.4 | 5.60E−04 |
Lipopolysaccharide biosynthetic process | 0.3 | 8.03E−03 | Cell junction organization | 0.4 | 6.10E−04 |
96 h | 96 h | ||||
Translational termination | 0.0 | 6.80E−24 | Notch signaling pathway | 0.3 | 8.20E−05 |
Nuclear-transcribed mRNA catabolic process | 0.1 | 1.70E−22 | Response to endoplasmic reticulum stress | 0.4 | 8.20E−05 |
Cotranslational protein targeting to membrane | 0.0 | 1.60E−21 | Peptidyl-proline hydroxylation | 0.2 | 2.17E−03 |
Protein targeting to ER | 0.0 | 3.90E−21 | Post-translational protein modification | 0.3 | 2.17E−03 |
SRP-dependent cotranslational protein targeting to membrane | 0.0 | 4.70E−21 | Positive regulation of gene expression (epigenetic) | 0.3 | 2.91E−03 |
Protein localization to endoplasmic reticulum | 0.0 | 4.80E−21 | Regulation of mRNA catabolic process | 0.3 | 2.95E−03 |
Establishment of protein localization to endoplasmic reticulum | 0.0 | 2.10E−20 | Maintenance of protein localization in organelle | 0.1 | 3.35E−03 |
Nuclear-transcribed mRNA catabolic process | 0.1 | 4.10E−20 | Maintenance of protein localization in endoplasmic reticulum | 0.0 | 3.35E−03 |
mRNA catabolic process | 0.1 | 2.70E−19 | Notch signaling involved in heart development | 0.2 | 3.98E−03 |
Translational initiation | 0.1 | 1.00E−18 | Vesicle targeting to, from or within Golgi | 0.0 | 4.03E−03 |