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Table 1 Segmental heterogeneity in the brain microvasculature endothelial cells (arterioles, capillaries and venules).

From: Advancing brain barriers RNA sequencing: guidelines from experimental design to publication

  Arterioles Capillaries References
Cells
 Smooth muscle cells Yes No [13, 30]
 Pericytes Yes/No Yes [13, 31]
 Perivascular macrophages Yes Yes [13, 30]
BBB features
 Tight junctions (TJs) Continuous and elaborate TJs/? Highly expressed TJs [29, 32, 33]
 Permeability for BBB markers ? No [30, 34]
 Astrocytic end-foot shealth No Yes [29, 30]
Transporters/enzymes/receptors
 P-glycoprotein ? +++ [35, 36]
 Na+/K+-ATPase +++ + [29]
 Transferrin receptor (TFRC) +++ [13, 37]
 Alkaline phosphatase +++ +++ [29]
 Mg2+-ATPase +++ + [29]
 5′-nucleotidase +++ + [29]
 γ-Glutamyl transpeptidase (GGTP) ? +++ [38, 39]
 Bidirectiona/l vesicular horsedish peroxidase transport +++ + [29, 40]
  1. Presence of perivascular cells is indicated by Yes/No. Presence of BBB features is indicated by Yes/No/non determined (n.d.). Relative expression of transporters/enzymes is indicated by +, ++ or +++ from lowest to highest expression