Fig. 8
Histological examination of brains from implanted animals: The areas of interest were cerebral cortex were the sensor tip approximately had been placed. a Whole brain sections from control (non-implanted) and animals implanted with the telemetric device for 50 days (implanted). Ventricular morphology was similar in control and implanted rats, showing no signs of ventriculomegaly and hydrocephalus in the implanted animals (arrows). b The cerebral cortex at higher magnification from control (non-implanted) and implanted brains for 50 days. The tissues from implanted rats were intact with no signs of tissue damage or bleeding when compared to tissue from non-implanted rats. c Histological examination of choroid plexus (CP). The morphology of the CP structures was similar in tissue from implanted rats for 50 days (implanted) compared to tissue from non-implanted rats (control). The morphology of CP was normal in all animals; the ependymal cells lining the ventricles with the apical side of the membrane facing the lumen of the ventricle was clearly defined as well as the basolateral side of the membrane facing the blood capillaries (arrows). d Assessment of GFAP staining in implanted and non-implanted brains. Upper panel shows representative micrographs of the contralateral and ipsilateral cortices of implanted brains with graph of GFAP intensity. Lower panel shows representative micrographs of corpus callosum of implanted and non-implanted (control) brains and graph with GFAP intensity in cortex. n = 3 control, n = 8 implanted. t-test for corpus callosum and paired t-test for cortical intensity measurement. Data presented as mean ± SEM