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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

Fig. 4

Impact of the DIPG environment on the transport of drugs across the BBB and BBTB. Endothelial permeability coefficient of the chemotherapeutic compounds a temozolomide and b panobinostat, after 7 days of incubation of the BBB cells with astrocytes (control), or DIPG cell lines DIPG-007, DIPG-013 and DIPG-014. c For each condition, the endothelial permeability coefficient (Pe) and the mass balance (MB) of the compounds were calculated. **p < 0.01; *p < 0.05. N = 2; n = 6

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Fluids and Barriers of the CNS

ISSN: 2045-8118