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Table 1 Geometric and hydrodynamic results

From: Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

Parameter

Control

Avg.a ± std.

ALS

Avg.a ± std.

Perimeter SC (cm)

1.87 ± 0.22

1.88 ± 0.26

Perimeter DM (cm)

5.66 ± 0.78

5.25 ± 0.83

Perimeter SSS (cm)

7.53 ± 0.89

7.13 ± 0.96

Cross-sectional area SC (cm2)

0.35 ± 0.07

0.35 ± 0.08

Cross-sectional area DM (cm2)

2.13 ± 0.54

1.89 ± 0.49

Cross-sectional area SSS (cm2)

1.78 ± 0.53

1.53 ± 0.48

Volume SC (Vc) (cm3)

20.99 ± 2.55

22.53 ± 2.29

Volume DM (Vd) (cm3)

129.19 ± 18.67

119.83 ± 21.74

Volume SSS (Vcs) (cm3)

108.20 ± 18.67

97.30 ± 20.51

Surface area SC (cm2)

113.52 ± 7.67

119.37 ± 6.59

Surface area DM (cm2)

344.12 ± 27.30

333.54 ± 39.72

Surface area SSS (cm2)

457.64 ± 29.89

452.91 ± 43.82

Hydraulic diameter (cm)

0.96 ± 0.21

0.89 ± 0.21

Reynolds number (cm)

194.74 ± 80.75

209.37 ± 37.34

Womersley number (α)

12.71 ± 1.48

11.92 ± 1.51

Usys (cm/s)

− 1.30 ± 0.34

− 1.29 ± 0.33

Udia (cm/s)

0.76 ± 0.30

0.70 ± 0.28

Qsys (cm3/s)

− 1.88 ± 0.62

− 1.58 ± 0.31

Qdia (cm3/s)

1.06 ± 0.29

0.83 ± 0.17

PWV (cm/s)

347.41 ± 88.13

473.19 ± 162.04

  1. DM dura matter, PWV pulse wave velocity, SC spinal cord, SSS spinal subarachnoid space, Qdia average diastolic CSF flowrate, Qsys average systolic CSF flowrate, Usys average systolic CSF velocity, Udia average diastolic CSF velocity
  2. aAverage values are based 1 mm slice intervals along the entire spine
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Fluids and Barriers of the CNS

ISSN: 2045-8118