Fig. 5

Evaluation of oxygen supply to tissue engineered ONMs and comparison of expression of hypoxia-related genes under physiological (phys.) vs. pathophysiological (pathphys.) perfusion conditions. a Oxygen saturation following reduction of perfusion rate to 0.01 mm/s (2.4% of physiological flow, relative to oxygen saturation under physiological flow). Shown is average of two independent experiments with two biological replicates each (S.D. in grey). b Expression heatmap showing Euclidian sample-to-sample distance matrix with hierarchical clustering of 362 hypoxia regulated genes in the 2 treatment groups. c Blot depicting significantly impacted hypoxia regulated genes