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Table 7 Parameters and units of intra-extracellular exchange. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter

Value (rat)

Value (human)

k′, cellular uptake rate (s−1)

2.4–19.0 [129]

0.22–304.3 [111]

CLcell, cellular transfer clearance (10−6 L s−1)

8 × 10−2–2.3 × 103 [143]

4.2 × 103–3 × 105 [227]

VICF, volume ICF (L)

1.44 [171]

960 [171]

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Fluids and Barriers of the CNS

ISSN: 2045-8118