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Table 7 Parameters and units of intra-extracellular exchange. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter Value (rat) Value (human)
k′, cellular uptake rate (s−1) 2.4–19.0 [129] 0.22–304.3 [111]
CLcell, cellular transfer clearance (10−6 L s−1) 8 × 10−2–2.3 × 103 [143] 4.2 × 103–3 × 105 [227]
VICF, volume ICF (L) 1.44 [171] 960 [171]
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Fluids and Barriers of the CNS

ISSN: 2045-8118