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Table 6 Parameters and units of drug transport within the brain tissue. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter Value (rat) Value (human)
D*, effective diffusion constant (10−10 m−2 s−1) 0.1–1 [129, 203] 0.1–15 [131, 189, 235]
\(\lambda\), tortuosity 1.44–3.5 [69, 168] 1.50–1.77 [69]
\(\alpha\), brain ECF volume fraction 0.05–0.47 [168] 0.23–0.49 [69, 111]
vECF, brain ECF bulk flow velocity (10−7 m s−1) 0.5–50 [22, 236] 2–8 [132]
CSF flow rate (10−7 L s−1) 0.37 [27, 220] 50–67 [237]