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Table 4 Parameters and units of the brain capillary system. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter

Value (rat)

Value (human)

Capillary radius (10−6 m)

0.8–4.8 [4, 5, 7, 213]

3−5 [17, 214, 215]

S, capillary surface area (m2)

1.3 [216]

15–25 [17, 113, 217]

Intercapillary distance (10−6 m)

14–72 [4, 5, 213]

40 [17, 129, 218]–60 [214]

Q, capillary blood flow rate (10−9 L min−1)

4.82–8.83 [219]

0.3–200 [114]

Vbrain, brain volume (g)

1.8 [171, 220]

1400 [41]

Capillary blood flow velocity (10−4 m s−1)

0.5−50 [221,222,223,224,225,226]

–