Table 4 Parameters and units of the brain capillary system. The physiological range of values of the parameters is given for rat and human, based on references from the literature
From: The need for mathematical modelling of spatial drug distribution within the brain
| Parameter | Value (rat) | Value (human) |
|---|---|---|
| Capillary radius (10−6 m) | 0.8–4.8 [4, 5, 7, 213] | 3−5 [17, 214, 215] |
| S, capillary surface area (m2) | 1.3 [216] | 15–25 [17, 113, 217] |
| Intercapillary distance (10−6 m) | 14–72 [4, 5, 213] | 40 [17, 129, 218]–60 [214] |
| Q, capillary blood flow rate (10−9 L min−1) | 4.82–8.83 [219] | 0.3–200 [114] |
| Vbrain, brain volume (g) | 1.8 [171, 220] | 1400 [41] |
| Capillary blood flow velocity (10−4 m s−1) | 0.5−50 [221,222,223,224,225,226] | – |