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Table 4 Parameters and units of the brain capillary system. The physiological range of values of the parameters is given for rat and human, based on references from the literature

From: The need for mathematical modelling of spatial drug distribution within the brain

Parameter Value (rat) Value (human)
Capillary radius (10−6 m) 0.8–4.8 [4, 5, 7, 213] 3−5 [17, 214, 215]
S, capillary surface area (m2) 1.3 [216] 15–25 [17, 113, 217]
Intercapillary distance (10−6 m) 14–72 [4, 5, 213] 40 [17, 129, 218]–60 [214]
Q, capillary blood flow rate (10−9 L min−1) 4.82–8.83 [219] 0.3–200 [114]
Vbrain, brain volume (g) 1.8 [171, 220] 1400 [41]
Capillary blood flow velocity (10−4 m s−1) 0.5−50 [221,222,223,224,225,226]