Fig. 10

Model on drug transport within the brain capillaries, active drug transport across the BBB and subsequent metabolism [125]. Spatial differences within the brain are, however, not considered. Left: a simplified model for active drug transport within the capillaries, across the BBB and subsequent metabolism [125]. The black circles represent the drug. Right: a schematic depiction of the lattice refinement process [125]. A cubic lattice (blue) represents a piece of brain tissue with a volume of 1 cm³. The cubic lattice can be replaced by a network of smaller cubic lattices (red). The larger blue unit and the multiple smaller units fill out the same computational volume. The arrow indicates the direction of the blood flow through the large unit. Both images by [125] are licensed under CC BY 4.0