Fig. 1

Schematic drawing of the experimental setup with a PMMA box containing the parenchyma (gray) with an enclosed ventricular system (blue), the cranial subarachnoid space and the spinal canal. The arteriovenous (AV) blood flow is reproduced by a pulsatile pump (red) connected to the cranial compliance chamber. Valve 1 adjusts the pulsation from the cranial SAS to the parenchyma, transmitted by the surrounding water in the box (dark red) and Valve 2 represents the resistance of the cranial SAS. Cranial and spinal compliance chambers are filled with air (light blue) in addition to the CSF (dark blue)