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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases

Fig. 3

Representation of the relationship between the Monro–Kellie hypothesis, intracranial pressure (ICP) and cerebral perfusion pressure (CPP). Values are based on a baseline mean arterial pressure (MAP) of 80 mmHg. In the compensated model, an increase in cerebral blood volume produces a decrease in cerebrospinal fluid (CSF) volume; this allows ICP and CPP to remain at baseline level. In the model of no compensation, there is no decrease in either cerebral blood volume or brain tissue following an increase in CSF volume; this causes ICP to rise to pathological levels and CPP to decrease in line with the relationship between CPP and ICP (CPP = MAP − ICP)

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