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Table 2 Model parameters and variables

From: Analysis of convective and diffusive transport in the brain interstitium

Parameter Value References
All simulations
 Arteriole diameter 30 μm Iliff [34], Xiong [44], Mestre [16] (40 μm); other modeling studies: Jin [38], Holter [35]
 Venule diameter 30 μm Iliff [34], Xiong [44]; other modeling studies: Jin [38] (40 μm), Holter [35]
Flow simulations
 Vessel separation (distance between arterioles and venules) 250 μm Nishimura [22] (175 μm rats), Adams [21] (280 μm primates), other modeling studies: Jin [38] (250 μm), Holter [35] (280 μm)
RTI and clearance simulations
 RTI current From appropriate experiment Cserr [30], Kress [25], Xie [24]
 Free diffusivity As reported for each molecule in “Methods” or “Results Nicholson [14]
 Void volume Mean value from appropriate experimental data Cserr [30], Kress [25], Xie [24]
 Tortuosity Fitted. Increased from experimental mean value to fit RTI data. See “Discussion” of adjusted tortuosity Cserr [30], Kress [25], Xie [24]
 Variables Value range References
Flow simulations
 Hydraulic conductivity 2 × 10−6 to 2 × 10−8 cm2 mmHg−1 s−1 See Table 3
 Pressure at arteriolar PVW 0.2 to 8 mmHg See Table 3
RTI and clearance simulations
 Bulk flow velocity 0 to 250 μm min−1 By adjusting hydraulic conductivity and pressure within above ranges
 PVW diffusivity 0.6 to 100% of DECS Mathiisen [10], Korogod [13], (see “Methods”)
 Vessel separation (distance between arterioles and venules) 225–275 μm Nishimura [22] (175 μm rats), Adams [21] (280 μm primates), other modeling studies: Jin [38] (250 μm), Holter [35] (280 μm)
  1. Parameters are held constant; they are either taken from literature or fitted from experimental data. Variables are varied to test different transport hypotheses (see Table 4)