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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate

Fig. 2

Metabolic activity of topiramate-treated CD-1 mice. Metabolic data collected from the laboratory animal monitoring system (CLAMS) after 1 week and 16 weeks of TPM administration as a preventative (arm 1) or efficacy (arm 2) agent from LF diet + saline (n = 8), LF diet + TPM (n = 8), HF diet + saline (n = 8), and HF diet + TPM (n = 8) in each arm. Mice were administered treatments once daily and measured for 72 h. Data collected includes a oxygen consumption (VO2; mL/h/kg), b energy expenditure (kcal/h), c food intake (FI; grams/h), d respiratory quotient (RQ: VCO2/VO2), e total activity (beam breaks/h), and f ambulatory activity (sequential beam breaks/h). Values are expressed as mean ± SD. Significance was determined by a one-way analysis of variance followed by Newman–Keuls post-test between HF vs. LF, LF vs. LF TPM, and HF vs. HF TPM. *p < 0.05; #p < 0.001

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